Anemia induced by irbesartan
10.3760/cma.j.cn114015-20201209-01224
- VernacularTitle:厄贝沙坦致贫血
- Author:
Dongxue WANG
1
;
Yingchun CUI
;
Feng XU
Author Information
1. 吉林大学第二医院药学部，长春 130041
- Publication Type:Journal Article
- Keywords:
Irbesartan;
Proteinuria;
Anemia
- From:
Adverse Drug Reactions Journal
2021;23(10):542-543
- CountryChina
- Language:Chinese
-
Abstract:
A 47-year-old male patient received irbesartan 225 mg orally once daily due to nephrotic syndrome. Three days later, the dose was changed to 300 mg once daily according to the doctor′s advice. His hemoglobin (Hb) was 153 g/L before irbesartan treatment. After 6 days of medication, the patient developed fatigue and weakness. Laboratory test showed that his Hb was 89 g/L. No laboratory test abnormality was found in serum creatinine, stool routine, and bone marrow puncture. After 13 days of medication, his Hb was 87 g/L. Moderate anemia related to irbesartan was diagnosed. Irbesartan was discontinued and IV infusion of methylprednisolone sodium succinate for injection 60 mg once daily and subcutaneous injection of erythropoietin 3 000 U thrice a week were given. Seven days later, the symptoms of fatigue and weakness were improved and laboratory test showed Hb 102 g/L. Twenty-seven days later, his Hb returned to 131 g/L.
