Transient pulmonary hypertension secondary to anaphylaxis due to cisatracurium
10.3760/cma.j.cn114015-20201228-01291
- VernacularTitle:顺式阿曲库铵过敏致一过性肺动脉高压
- Author:
Helin ZENG
1
;
Zhimin LIAO
1
Author Information
1. 四川大学华西第二医院麻醉科/出生缺陷与相关妇儿疾病教育部重点实验室，成都 610041
- Publication Type:Journal Article
- Keywords:
Atracurium;
Hypoxia;
Hypertension, pulmonary;
Drug-related side effects and adverse reactions
- From:
Adverse Drug Reactions Journal
2021;23(9):502-504
- CountryChina
- Language:Chinese
-
Abstract:
A 49-year-old female patient underwent laparoscopic exploration under general anesthesia due to bilateral tubal abscess complicated with acute renal failure. During anesthesia induction, midazolam, sufentanil, cisatracurium, and propofol were used successively, resulting in severe hypoxemia with the lowest pulse oxygen saturation of 0.57. Echocardiography showed right heart enlargement, tricuspid regurgitation, and pulmonary hypertension (estimated pulmonary artery pressure 62 mmHg). Through tracheal intubation, assisted breathing with mechanical ventilation, and treatments with hydrocortisone and papaverine, the hypoxemia was corrected and the operation was completed successfully. Echocardiography showed the pulmonary artery pressure returned to normal on the 2nd day after operation. The patient was determined to be hypersensitive to cisatracurium by a needle skin test on the 9th postoperative day. It was considered that the transient pulmonary hypertension in the patient was caused by pulmonary vasospasm due to allergic reaction to the drug.
