Advances in targeting mitochondrial quality control against ischemic stroke and its herbal medicine therapy
- VernacularTitle:靶向线粒体质量控制防治缺血性脑卒中及其中医药治疗进展
- Author:
Yi ZHANG
1
;
Chuan-zhen DAI
;
Wei-juan GAO
Author Information
- Publication Type:Journal Article
- Keywords: mitochondrial quality control; stroke; ischemic stroke; traditional Chinese medicine; mechanism; research pro-gress
- From: Chinese Pharmacological Bulletin 2025;41(8):1424-1431
- CountryChina
- Language:Chinese
- Abstract: Ischemic stroke is a sudden neurological disorder caused by local cerebral ischemia and persistent cerebral infarc-tion due to impaired blood supply of the brain.IS,with a high disability and mortality rate,is a high incidence disease in Chi-na.Mitochondria play a central role in the pathological and physiological processes of IS.Mitochondrial quality control(MQC)is the cornerstone of maintaining mitochondrial function and the integrity of mitochondrial network,playing an indispen-sable role in promoting neuronal survival and restoring neural vascular unit homeostasis after IS.IS belongs to stroke in tradi-tional Chinese medicine,and is the first of the four major diffi-cult diseases of"stroke,phthisis,swell,and dysphagia".The syndrome of IS belongs to the deficiency in origin and excess in superficies.Traditional Chinese medicine has thousands of years of experience in treating ischemic stroke.Numerous pharmaco-logical studies have found that the therapeutic effect of traditional Chinese medicine on ischemic stroke is closely related to the mechanism of mitochondrial quality control.Therefore,this arti-cle provides a review of the mechanism of MQC in IS and tradi-tional Chinese medicine targeted intervention for MQC,in order to provide reference and inspiration for new treatment for IS.
