Acute tubulointerstitial nephritis caused by oral moxifloxacin
10.3760/cma.j.cn114015-20201225-01284
- VernacularTitle:口服莫西沙星致急性肾小管间质性肾炎
- Author:
Dongxue WANG
1
;
Jiqiu HOU
;
Feng XU
Author Information
1. 吉林大学第二医院药学部，长春 130041
- Publication Type:Journal Article
- Keywords:
Moxifloxacin;
Nephritis, interstitial;
Acute kidney injury
- From:
Adverse Drug Reactions Journal
2021;23(9):491-492
- CountryChina
- Language:Chinese
-
Abstract:
A 44-year-old male patient received moxifloxacin 0.4 g orally once daily for pulmonary infection. He had normal renal function with serum creatinine (Scr) 67 μmol/L before treatment. Three days after medication, the patient developed abdominal pain, vomiting, oliguria, and 5 days later, laboratory tests showed Scr 1 372 μmol/L, blood urea nitrogen (BUN) 30.5 mmol/L, and estimated glomerular filtration rate (eGFR) 3.3 ml/(min·1.73 m 2). Acute tubulointerstitial nephritis was diagnosed by renal puncture and pathological examination. Drug-induced kidney injury was considered, which might be related to moxifloxacin. Moxifloxacin was discontinued and hemodialysis, anti-infection, and symptomatic treatments were given. The patient′s urine volume gradually recovered and renal function was improved. Fifteen days later, his Scr was 293 μmol/L and BUN was 10.5 mmol/L. One and a half months later, the Scr was 185 μmol/L and BUN was 9.8 mmol/L.
