Stevens-Johnson syndrome induced by sodium valproate oral solution in a child
10.3760/cma.j.cn114015-20201222-01267
- VernacularTitle:丙戊酸钠口服液致幼儿Stevens-Johnson综合征
- Author:
Kangkang MEI
1
;
Didi ZHAN
1
;
Zhihong LUO
1
;
Heping CAI
1
Author Information
1. 安徽省儿童医院药剂科，合肥 230051
- Publication Type:Journal Article
- Keywords:
Stevens-Johnson syndrome;
Erythema multiforme;
Valproic acid
- From:
Adverse Drug Reactions Journal
2021;23(9):500-502
- CountryChina
- Language:Chinese
-
Abstract:
A 1-year and 4 month-old boy with epilepsy received sodium valproate oral solution 2.5 ml twice daily, Shengxue Tiaoyuan decoction (升血调元汤) 6 ml twice daily and five vitamins and calcium gluconate oral solution 3 ml twice daily. On day 13 of treatments, the boy developed red maculopapular rashes and blisters all over the body, some of which fused into pieces; his bilateral conjunctiva slightly congested with secretions, mouth and lip mucosa congested and eroded, and a few maculopapular rashes appeared on the external genitalia. At the same time, the boy′s body temperature rose up to 40.0 ℃. Stevens-Johnson syndrome was diagnosed, which was considered to be related to sodium valproate oral solution. The drug was stopped immediately and treatments such as blood perfusion, infusion of plasma and red blood cells, anti-infection and hormone therapy, and eye and skin care were given. On the 17th day of treatments after drug withdrawal, the rashes on the whole body subsided, ulceration scabbed, erosion of oral and lip mucosa cured, and conjunctival congestion disappeared.
