Analysis of the effects of compound Qinlan oral liquid combined with azithromycin on immune indicators and clinical symptoms in children with Mycoplasma pneumoniae pneumonia
10.13431/j.cnki.immunol.j.20250051
- VernacularTitle:复方芩兰口服液联合阿奇霉素对肺炎支原体肺炎患儿免疫指标及临床症状的影响
- Author:
Xinhui ZHANG
1
;
Wenxuan DONG
1
Author Information
1. 335000,鹰潭市中医院儿科
- Publication Type:Journal Article
- Keywords:
Compound Qinlan Oral Liquid;
Azithromycin;
Mycoplasma pneumoniae pneumonia
- From:
Immunological Journal
2025;41(5):345-349,355
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the therapeutic effect of compound Qinlan oral liquid combined with azithromycin on children with Mycoplasma pneumoniae pneumonia.Methods 100 children with Mycoplasma pneumoniae pneumonia admitted to the hospital from January 2021 to December 2023 were randomly divided into two groups based on a 1︰1 ratio.The control group(n=50)received sequential treatment with azithromycin,administered intravenously at a dose of 10 mg/kg,once a day,for 3 consecutive days;Oral administration of azithromycin,dosage:12 mg/kg,once a day,for 4 consecutive days;After stopping the medication for 3 days,the next course of treatment can be initiated;The observation group(n=50)received the same dosage and administration of azithromycin as the control group.One compound Qinlan oral solution was taken orally,twice a day,for 14 consecutive days;Compare the treatment effects,immune indicators,lung function,serum inflammation indicators,etc.between the two groups.Results The treatment effect of the observation group was 96.00％,higher than that of the control group 80.00％,with a significant difference(x2=6.061,P=0.014);The disappearance time of various clinical symptoms in the observation group was shorter than that in the control group,and the improvement in lung function after treatment was higher than that in the control group(P＜0.05).The improvement in various immune functions in the observation group after treatment was higher than that in the control group,with INF-γ,IL-2,IL-4,C-reactive protein(CRP),and white blood cell count were lower in the control group,while the proportion of neutrophils and lymphocytes was higher in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(10.00％ vs 14.00％)(P＞0.05).Conclusion The combination of compound qinlan oral liquid and azithromycin has achieved ideal results in the treatment of Mycoplasma pneumoniae pneumonia,which can improve the immune function of children,and reduce serum inflammatory expression.
