Anaphylactic shock caused by sulphur hexafluoride microbubbles for injection
10.3760/cma.j.cn114015-20210305-00271
- VernacularTitle:注射用六氟化硫微泡致过敏性休克
- Author:
Huanqing MA
1
;
Changxing MA
;
Erfeng ZHANG
;
Bo SUN
Author Information
1. 河南大学肿瘤医院/郑州市第三人民医院药学部，郑州 450099
- Publication Type:Journal Article
- Keywords:
Contrast media;
Sulfur hexafluoride;
Microbubbles;
Anaphylaxis;
Shock
- From:
Adverse Drug Reactions Journal
2022;24(1):40-42
- CountryChina
- Language:Chinese
-
Abstract:
A 74-year-old male patient was hospitalized for cerebral infarction, hypertension, diabetes mellitus, and coronary atherosclerotic heart disease. During the hospitalization, a thyroid ultrasound examination revealed suspicious nodules. In order to make a definite diagnosis, thyroid ultrasonography was performed, during which 2.4 ml of sulphur hexafluoride microbubbles for injection and 5 ml of 0.9% sodium chloride injection were given intravenously. Ten minutes later, the patient developed fever, confusion, profuse sweating, red skin rash, and blood pressure 80/60 mmHg, and anaphylactic shock caused by sulphur hexafluoride microbubbles for injection was considered. The patient was given intravenous injection of dexamethasone 10 mg, intravenous infusion of adrenaline 1 mg dissolved in 0.9% sodium chloride injection 250 ml, intramuscular injection of promethazine 25 mg, and mask oxygen. About 3 minutes later, the patient′s consciousness gradually turned clear, and the blood pressure rose (103/72 mmHg); 1.5 hours later, the patient′s consciousness was completely recovered, the blood pressure was 143/86 mmHg, the heart rate was 98 beats/min, and the blood oxygen saturation was 0.98. Twenty-four hours later, the rash was basically disappeared, and the patient′s condition was stable.
