Pharmacological effects and clinical evaluation of toludesvenlafaxine in the treatment of depression
10.12092/j.issn.1009-2501.2025.03.016
- VernacularTitle:托鲁地文拉法辛治疗抑郁症的药理作用与临床评价
- Author:
Yumeng LI
1
;
Xiaoyu DU
;
Bo QIU
;
Huizhen WU
Author Information
1. 河北医科大学研究生学院,石家庄 050017,河北;河北省人民医院药学部,河北省临床药学重点实验室,石家庄 050051,河北
- Publication Type:Journal Article
- Keywords:
depression;
toludesvenlafaxine;
5-HT/NE/DA triple reuptake inhibitor
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(3):419-426
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a common mental dis-ease.At present,there are poor efficacy and drug-related safety problems in antidepressant treat-ment.Toludesvenlafaxine,as a new triple reuptake inhibitor(TRIs/SNDRIs),increases the inhibitory ef-fect of dopamine(DA)reuptake on the basis of se-rotonin(5-HT)and norepinephrine(NE),achieves multi-target synergistic therapy and reduces 5-HT/NE-related adverse drug reactions.This article re-views the basic introduction,preclinical research,clinical efficacy and safety of toludesvenlafaxine,in order to provide more ideas and options for the treatment of depression.
