Acute poisoning caused by large-dose of phenobarbital and scopolamine hydrobromide
10.3760/cma.j.cn114015-20210515-00581
- VernacularTitle:大剂量苯巴比妥东莨菪碱致急性中毒
- Author:
Bo SUN
1
;
Xun LIU
;
Erfeng ZHANG
;
Huanqing MA
Author Information
1. 郑州市第三人民医院药学部，郑州 450099
- Publication Type:Journal Article
- Keywords:
Phenobarbital;
Scopolamine;
Drug overdose;
Poisoning;
Tetany
- From:
Adverse Drug Reactions Journal
2021;23(11):612-614
- CountryChina
- Language:Chinese
-
Abstract:
A 25-year-old male patient took about 60 tablets of phenobarbital and scopolamine hydrobromide by himself (each tablet contains 30 mg phenobarbital and 0.2 mg scopolamine hydrobromide). About 1 hour later, he developed coma with paroxysmal limb convulsions. Drug poisoning was diagnosed. The patient received gastric lavage, catharsis, and intravenous injection of midazolam 10 mg for epilepsy. Six hours later, his heart rate was 53 beats/min, breathing rate was 11 times/min, and occasional convulsions and hematuria occurred. Laboratory tests showed indirect bilirubin 16.97 μmol/L, total protein 54 g/L, albumin 27.6 g/L, and thrombin time 25.0 s. Multiple organ injury was considered and blood purification treatment was given. One day later, the patient′s consciousness was restored, heart rate was 68 beats/min, breathing rate was 16 times/min, and no convulsion occurred. Laboratory tests showed indirect bilirubin 8.69 μmol/L, total protein 54.7 g/L, albumin 34.0 g/L, and thrombin time 16.7 s.
