Exfoliative dermatitis related to oxaliplatin and mannitol injection
10.3760/cma.j.cn114015-20201123-01167
- VernacularTitle:奥沙利铂甘露醇注射液致剥脱性皮炎
- Author:
Haiyan LIU
1
;
Qiuli MIAO
1
;
Yanqing SONG
1
;
Xiangfeng WANG
1
Author Information
1. 吉林大学第一医院药学部，长春 130021
- Publication Type:Journal Article
- Keywords:
Oxaliplatin;
Dermatitis, exfoliative;
Drug-related side effects and adverse reactions;
Skin diseases, papulosquamous
- From:
Adverse Drug Reactions Journal
2021;23(7):384-386
- CountryChina
- Language:Chinese
-
Abstract:
A 62-year-old female patient with stomach cancer received an IV infusion of oxaliplatin and mannitol injection on day 1 and oral tegafur, gimeracil, and oteracil potassium on days 1-14 in a 21-day cycle after radical mastectomy. Pretreatment with dexamethasone and other drugs was given 3 hours before the infusion to alleviate possible adverse reactions. During the 1st cycle of chemotherapy, the patient had no other adverse reaction except nausea and fatigue, and no intervention was given. About 2 hours after oxaliplatin and mannitol injection in the 2nd cycle, the patient′s limbs were swollen and flushed, and red patches appeared on the skin. Then the erythema increased and merged into patches and her skin on the feet was desquamated. The above symptoms were improved after anti-allergic treatments. About 3 hours after oxaliplatin and mannitol injection in the 3rd cycle, the patient developed dyspnea, and systemic skin flushing and swelling accompanied by scratches. Then visible blisters on part of the skin appeared, which cracked at the flexion of the joints with exudate impregnation. The patient was given anti-allergic therapy such as prednisolone. Four days later, her skin on the whole body showed scaly desquamation, her hands and feet showed gloved desquamation, and she was diagnosed as having exfoliative dermatitis; 9 days later, her skin color became lighter and there was no new rash. Considering that exfoliative dermatitis was caused by oxaliplatin and mannitol injection, the chemotherapy regimen was switched to docetaxel (day 1) and tegafur, gimeracil, and oteracil potassium (days 1-14). The skin allergic reactions did not recur.
