A comparative analysis on adverse reactions of oxycodone hydrochloride prolonged-release tablets and fentanyl transdermal system for moderate to severe cancer pain
10.3760/cma.j.cn114015-20201222-01266
- VernacularTitle:盐酸羟考酮缓释片与芬太尼透皮贴剂治疗中重度癌症疼痛的不良反应比较分析
- Author:
Juan LUO
1
;
Qi YUAN
1
;
Changdong DIAO
1
;
Xu CHEN
1
;
Li FAN
1
;
Chen SHI
1
Author Information
1. 华中科技大学同济医学院附属协和医院药学部，武汉 430022
- Publication Type:Journal Article
- Keywords:
Analgesics, opioid;
Cancer pain;
Oxycodone;
Fentanyl
- From:
Adverse Drug Reactions Journal
2021;23(7):361-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the adverse reactions of oxycodone hydrochloride prolonged-release tablets and fentanyl transdermal system in the treatment of moderate and severe cancer pain.Methods:The medical records of patients with moderate to severe cancer pain who used oxycodone hydrochloride prolonged-release tablets (oxycodone group) or fentanyl transdermal systems (fentanyl group) for more than 1 week during hospitalization in Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology from January 2018 to December 2019 were collected. The occurrence of adverse reactions after analgesic treatments were retrospectively analyzed.Results:A total of 698 patients were enrolled in the analysis, including 535 in the oxycodone group and 163 in the fentanyl group. The incidence of adverse reactions in the oxycodone group was significantly higher than that in the fentanyl group [72.5% (388/535) vs. 51.5% (84/163), χ2=25.139, P<0.001]. The common adverse reactions (with incidence ≥5%) in the oxycodone group were constipation, nausea/vomiting, xerostomia, drowsiness, and dizziness, while those in the fentanyl group were constipation, nausea/vomiting, and dizziness. The incidence of constipation in the oxycodone group was significantly higher than that in the fentanyl group [60.9% (326/535) vs. 40.5% (66/163), χ2=21.209, P<0.001]. The differences in the incidence of other adverse reactions in the 2 groups were not statistically significant (all P>0.05). All adverse reactions were grade 1 or 2, which were improved after symptomatic treatments. No adverse reactions of grade 3 or more severe occurred. Conclusions:Both oxycodone hydrochloride prolonged-release tablets and fentanyl transdermal system are safe during the treatment for moderate to severe cancer pain, with mild adverse reactions, which can be relieved by symptomatic treatments. Oxycodone hydrochloride prolonged-release tablets are more likely to cause constipation than fentanyl transdermal system.
