Liver injury caused by Fuyanshu capsules (妇炎舒胶囊) combined with traditional Chinese medicine decoction
10.3760/cma.j.cn114015-20201204-01212
- VernacularTitle:妇炎舒胶囊联合中药汤剂致肝损伤
- Author:
Feiyan ZHAO
1
;
Xialan ZHANG
1
;
Yuanyuan QIN
1
;
Qiuyue TANG
1
;
Dengyu ZHANG
1
;
Xikun SHEN
1
;
Yuyu HUANG
1
Author Information
1. 南京中医药大学苏州附属医院药学部，苏州 225009
- Publication Type:Journal Article
- Keywords:
Drugs, Chinese herbal;
Chemical and drug induced liver injury;
Drug therapy, combination
- From:
Adverse Drug Reactions Journal
2021;23(7):379-380
- CountryChina
- Language:Chinese
-
Abstract:
A 43-year-old female patient received Fuyanshu capsules 1.6 g orally thrice daily for pelvic inflammation. The traditional Chinese medicine decoction was added 1 week later. After 10 days of combination therapy, the patient developed fatigue, which was gradually aggravated, and yellowish skin and sclera appeared. Seven days later, laboratory tests showed alanine aminotransferase (ALT) >1 000 U/L, aspartate aminotransferase (AST) >750 U/L, gamma-glutamyltransferase (γ-GT) 148 U/L, alkaline phosphatase (ALP) 153 U/L, and total bilirubin (TBil) 56.3 μmol//L. After excluding viral hepatitis, autoimmune liver disease, obstructive jaundice, and other causes, liver injury caused by Fuyanshu capsules combined with traditional Chinese medicine decoction was considered. After Fuyanshu capsules and traditional Chinese medicine decoction were discontinued, reduced glutathione, glycyrrhizic acid preparation, and ursodeoxycholic acid were given. Seven days later, the patient′s symptoms were improved obviously and laboratory tests showed ALT 323 U/L, AST 125 U/L, γ-GT 149 U/L, ALP 109 U/L, and TBil 35.8 μmol/L. Twenty-seven days later, the patient′s symptoms disappeared and laboratory tests showed ALT 62 U/L, AST 42 U/L, γ-GT 67 U/L, ALP 67 U/L, and TBil 18.7 μmol/L. There are 7 same components in Fuyanshu capsule and traditional Chinese medicine decoction. It was considered that the liver injury was related to the increase of hepatotoxicity caused by the combination of the two drugs.
