Kidney injury and metatarsophalangeal joints pain induced by montelukast sodium
10.3760/cma.j.cn114015-20201203-01206
- VernacularTitle:孟鲁司特钠致肾损伤和跖趾关节疼痛
- Author:
Yanhua LI
1
;
Xu TIAN
;
Guangchen LIU
;
Hongmei ZHANG
Author Information
1. 吉林大学第一医院日间观察病房，长春 130021
- Publication Type:Journal Article
- Keywords:
Leukotriene antagonists;
Acute kidney injury;
Arthralgia;
Montelukast
- From:
Adverse Drug Reactions Journal
2021;23(7):377-378
- CountryChina
- Language:Chinese
-
Abstract:
A 60-year-old male patient was hospitalized due to acute attack of bronchial asthma and pneumonia and antitussive, antiasthmatic, and anti-inflammatory treatments was given. Then his symptoms were improved. Discharge medication included budesonide and formoterol fumarate powder for inhalation and montelukast sodium. On the 4th day of medication after discharge, the patient developed bilateral metatarsophalangeal joint pain with redness and swelling, abdominal distension, fatigue, and dark urine. Laboratory tests showed serum creatinine (Scr) 112 μmol/L, serum uric acid 228 μmoL/L, urine protein (+), and urine occult blood (++). Gout, rheumatoid arthritis, and other autoimmune diseases were excluded and the possibility of acute kidney injury and metatarsophalangeal joint pain related to montelukast sodium was considered. Montelukast sodium was discontinued, budesonide and formoterol fumarate powder for inhalation was continued, and symptomatic treatment was given at the same time. Seven days later, the pain of metatarsophalangeal joint was improved and the urine color returned to normal. Two weeks later, his Scr level returned to normal (75 μmol/L).
