Acute urinary retention with secondary acute kidney injury caused by paracetamol, pseudoepherine hydrochloride, dextromethorphan hydrobromide and chlorphenamine maleate in a patient with prostatic calculus
10.3760/cma.j.cn114015-20201008-01006
- VernacularTitle:酚麻美敏致前列腺结石患者急性尿潴留继发急性肾损伤
- Author:
Danyan ZHU
1
Author Information
1. 浙江省台州医院临床药学室，台州 317000
- Publication Type:Journal Article
- Keywords:
Chlorpheniramine;
Prostatic diseases;
Urinary retention;
Acute kidney injury
- From:
Adverse Drug Reactions Journal
2021;23(6):330-332
- CountryChina
- Language:Chinese
-
Abstract:
A 54-year-old male patient received furosemide, sacubitril and valsartan, trimebutine, and live combined bifidobacterium, lactobacillus and enterococcus capsules for heart failure, atrial fibrillation, abdominal distension, and diarrhea. The patient′s renal function was normal before medication and the serum creatinine (Scr) was 93 μmol/L. On day 2, due to the patient′s cough and sputum, paracetamol, pseudoepherine hydrochloride, dextromethorphan hydrobromide and chlorphenamine maleate (containing 325 mg paracetamol, 30 mg pseudoephedrine hydrochloride, 15 mg dextromethorphan hydrobromide and 2 mg chlorphenamine maleate in each tablet) 325 mg orally were added once every 6 hours. On day 3, the patient developed dysuria and lower abdominal pain. Laboratory tests showed Scr 215 μmol/L and B-type natriuretic peptide 0.091 μmol/L; emergency ultrasonography of urinary system showed prostatic calculus, normal prostate size, and full bladder. Considering that paracetamol, pseudoepherine hydrochloride, dextromethorphan hydrobromide and chlorphenamine maleate caused acute urinary retention and then acute kidney injury, the drug was stopped on that day and the other drugs were continued. On the 2nd day of drug withdrawal, the patient′s dysuria was relieved and Scr was 162 μmol/L; on the 3rd day of drug withdrawal, the patient′s symptoms disappeared and Scr was 134 μmol/L.
