Sperm donation utilization rates in nonobstructive azoospermia patients under diffe-rent testicular sperm retrieval methods during assisted reproductive technology cycles
10.19723/j.issn.1671-167X.2025.04.015
- VernacularTitle:辅助生殖技术周期中不同睾丸取精方式下非梗阻性无精子症患者的精子库供精比例
- Author:
Qianxi CHEN
1
;
Yan CHEN
1
;
Zhongjie ZHENG
1
;
Wenhao TANG
1
;
Zhen LIU
1
;
Kai HONG
1
;
Haocheng LIN
1
Author Information
1. 北京大学第三医院泌尿外科,北京 100191;北京大学第三医院生殖医学中心,北京 100191
- Publication Type:Journal Article
- Keywords:
Nonobstructive azoospermia;
Sperm banks;
Sperm retrieval;
Assisted reproductive tech-niques
- From:
Journal of Peking University(Health Sciences)
2025;57(4):721-726
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the proportion of nonobstructive azoospermia(NOA)patients opting for sperm bank donation under different sperm retrieval methods[percutaneous testicular sperm aspiration(TESA),microdissection testicular sperm extraction(mTESE)]and its influencing factors.Methods:Retrospective data from assisted reproductive technology(ART)cycles at the Center for Reproductive Medical,Peking University Third Hospital(from January 2019 to December 2023)were collected.Data-complete ART cycles involving NOA patients and their partners(using the last treatment cycle as the endpoint)were selected.Sperm donation utilization rates were compared across retrieval methods(fresh mTESE,fresh TESA,thawed mTESE,thawed TESA).Log-linear models were used to analyze the rela-tionship between sperm retrieval method and sperm source.Results:Among the 1 730 couples,the over-all sperm donation utilization rate was 12.66％.The highest rate occurred in the fresh mTESE group(23.42％),followed by the thawed mTESE group(5.87％).The rates for the fresh TESA and thawed TESA groups were 5.22％and 0％,respectively.Log-linear analysis demonstrated that sperm retrieval method was significantly associated with sperm source(mTESE:Estimate=4.499;TESA:Estimate=2.780;P＜0.001).Conclusion:The low overall sperm donation utilization rate in ART cycles may re-flect the efficacy of synchronous sperm retrieval ART.The proportion of NOA patients opting for sperm donation was influenced by the retrieval method.Compared with patients undergoing TESA,those under-going mTESE were more inclined to utilize donor sperm after retrieval failure.
