Rhabdomyolysis caused by gabapentin
10.3760/cma.j.cn114015-20201202-01198
- VernacularTitle:加巴喷丁致横纹肌溶解症
- Author:
Dongxue WANG
1
;
Jiqiu HOU
;
Feng XU
Author Information
1. 吉林大学第二医院药学部，长春 130041
- Publication Type:Journal Article
- Keywords:
Rhabdomyolysis;
Gabapentin
- From:
Adverse Drug Reactions Journal
2021;23(6):328-329
- CountryChina
- Language:Chinese
-
Abstract:
A 66-year-old female patient received gabapentin 0.3 g once daily for restless legs syndrome. After 3 days of medication, she developed muscle soreness, weakness of both legs, and dark brown urine. Laboratory tests showed myoglobin 2 855.0 μg/L, creatine kinase (CK) 3 009 U/L, CK-MB 61 U/L, serum creatinine (Scr) 542 μmol/L, urine protein (+++), and urine occult blood (+). Her lower limb muscle strength was grade 1. Rhabdomyolysis caused by gabapentin was considered. Then the drug was stopped, and the symptomatic treatments including rehydration, alkalized urine, diuresis, etc. were given. After 5 days of treatments, the patient′s dark brown urine and muscle soreness disappeared, weakness of both lower limbs was improved, and lower limb muscle strength returned to grade 3. Laboratory tests showed ALT 35 U/L, AST 55 U/L, myoglobin 929.0 μg/L, CK 325 U/L, Scr 557 μmol/L, urine protein (+), and urine occult blood ( -). At a 1-month follow-up, the symptoms above-mentioned did not recur. Laboratory tests showed ALT 30 U/L, AST 38 U/L, myoglobin 135.0 μg/L, and CK 187 U/L.
