Research Progress of Transporter-Mediated Drug-Drug Interaction Studies in New Drug Development
10.3870/j.issn.1004-0781.2025.04.016
- VernacularTitle:新药研发中基于转运体的药物-药物相互作用研究进展
- Author:
Shujun FU
1
;
Bin XIA
;
Luqin SI
;
Jiangeng HUANG
Author Information
1. 国家药品监督管理局药品审评中心,北京 100163
- Publication Type:Journal Article
- Keywords:
Transporters;
Drug-drug interaction;
New drug development
- From:
Herald of Medicine
2025;44(4):596-602
- CountryChina
- Language:Chinese
-
Abstract:
There are a large number of drug transporters widely distributed in various tissues and organs in the human body.They are involved in the membrane transport of numerous endogenous substances,toxins,and drugs.The transmembrane transport mediated by transporters not only plays an important role in maintaining the homeostasis of the internal environment,but also closely related to drug absorption,distribution,metabolism,and excretion processes.In clinical practice,drug-drug and drug-endogenous molecule interactions based on drug transporters may affect therapeutic efficacy or lead to toxic side effects.Therefore,it is particularly important to closely monitor and evaluate the risks of transporters mediated drug-drug interactions in the drug development and marketing process.This review summarized the classification,functions,tissue distribution and substrate specificity of typical drug transporters in new drug development.Subsequently,the research progress regarding drug-drug interactions involving 24 drug transporters for 55 newly approved drugs by the US Food and Drug Administration in 2023 is comprehensively reviewed.The aim is to provide reference for further drug-drug interaction research together with its scientific significance during new drug development stage.
