Study on the accuracy of resting full-cycle ratio,quantitative flow ratio,and contrast-induced fractional flow reserve in evaluating coronary artery borderline lesions
10.3969/j.issn.1004-8812.2025.03.007
- VernacularTitle:对比剂诱导的跨病变压力比值、静息全周期比值与定量血流分数评价冠状动脉临界病变准确性的研究
- Author:
Rui-tao ZHANG
1
;
Zhen-yu TIAN
1
;
Li-yun HE
1
;
Lin MI
1
;
Li-jun GUO
1
;
Xin-ye XU
1
Author Information
1. 北京大学第三医院心内科 血管医学研究所 血管稳态与重构全国重点实验室 国家卫生健康委心血管分子生物学与调节肽重点实验室 心血管受体研究北京市重点实验室,北京 100191
- Publication Type:Journal Article
- Keywords:
Contrast-induced fractional flow reserve;
Resting full-cycle ratio;
Quantitative flow ratio;
Fractional flow reserve;
Coronary artery functional assessment
- From:
Chinese Journal of Interventional Cardiology
2025;33(3):163-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the accuracy and clinical application value of contrast-induced fractional flow reserve(cFFR),resting full-cycle ratio(RFR),and quantitative flow ratio(QFR)in evaluating coronary artery borderline lesions,using fractional flow reserve(FFR)as the gold standard.Methods A retrospective study was conducted including 143 patients with 143 lesions who underwent coronary angiography(CAG)and were tested for cFFR,RFR,QFR,and FFR at Peking University Third Hospital from September 2020 to January 2022.Clinical data,CAG lesion anatomical data,and target vessel cFFR,RFR,QFR,and FFR measurements were collected.The correlation and diagnostic concordance of cFFR,RFR,QFR,and FFR were analyzed.Results The mean age of the 143 patients was 66(58,71)years,with 90(62.9％)being male.Among them,60(42.0％)patients were diagnosed with unstable angina,and 115(80.4％)target lesions were located in the left anterior descending artery.Correlation analysis showed that RFR,QFR,and cFFR were all significantly correlated with FFR(r=0.956,r=0.861,r=0.751,P＜0.001).Bland-Altman analysis demonstrated high agreement between cFFR,RFR,QFR,and FFR.Receiver operating characteristics(ROC)curve analysis showed that the area under the curve(AUC)for RFR corresponding to FFR ≤0.80 was 0.92(95％CI 0.87-0.96),for QFR was 0.89(95％CI 0.83-0.95),and for cFFR was 0.96(95％CI 0.94-0.99).Conclusions cFFR,RFR,and QFR show high concordance with FFR,with similar diagnostic consistency between the three methods and FFR.
