Acute kidney injury due to combination therapy with amoxicillin, furazolidone, rabeprazole, and bismuth for Helicobacter pylori infection
10.3760/cma.j.cn114015-20200316-00278
- VernacularTitle:阿莫西林、呋喃唑酮、雷贝拉唑和铋剂联用治疗幽门螺杆菌感染致急性肾损伤
- Author:
Shujuan WU
1
;
Ermin GU
;
Xiaolan YE
Author Information
1. 浙江省瑞安市人民医院/温州医科大学附属第三医院药学部，温州 325200
- Publication Type:Journal Article
- Keywords:
Amoxicillin;
Rabeprazole;
Furazolidone;
Bismuth;
Helicobacter pylori;
Acute kidney injury
- From:
Adverse Drug Reactions Journal
2021;23(1):45-46
- CountryChina
- Language:Chinese
-
Abstract:
A 58-year-old male patient received quadruple therapy with amoxicillin 1 g, furazolidone 0.1 g, rabeprazole 20 mg, and bismuth potassium citrate 0.6 g twice daily for Helicobacter pylori infection for 4 weeks. Seven days after drug withdrawal, the laboratory tests showed serum creatinine (Scr) 469 μmol/L and blood urea nitrogen (BUN) 19.2 mmol/L. Renal biopsy showed acute tubular injury. The Scr level was 78 μmol/L in the physical examination of 6 months ago. Acute kidney injury was considered to be associated with the quadruple therapy. Methylprednisolone, rebamipide, and calcium carbonate were given orally. Four weeks later, the laboratory tests showed Scr 171 μmol/L and BUN 14.4 mmol/L and the above treatments were continued; 12 weeks later, his Scr was 140 μmol/L and BUN was 11.4 mmol/L.
