Hemocytopenia caused by piperacillin sodium and tazobactam sodium misdiagnosed as gastrointestinal hemorrhage
10.3760/cma.j.cn114015-20200401-00344
- VernacularTitle:哌拉西林钠他唑巴坦钠致血细胞减少误诊为消化道出血
- Author:
Jiancheng LIU
1
;
Xin MA
1
;
Zhesi CHEN
1
;
Zesha LING
1
;
Wenchun WANG
1
Author Information
1. 中国人民解放军西部战区总医院康复医学科，成都 610083
- Publication Type:Journal Article
- Keywords:
Piperacillin;
Tazobactam;
Anemia;
Leukopenia;
Gastrointestinal hemorrhage
- From:
Adverse Drug Reactions Journal
2021;23(1):41-42
- CountryChina
- Language:Chinese
-
Abstract:
A 79-year-old male patient was given an IV infusion of piperacillin sodium and tazobactam sodium 4.5 g once every 8 hours for head injury complicated by Escherichia coli pneumonia. Before the treatment, his white blood cell count (WBC) was 10.20×10 9/L, red blood cell count (RBC) was 3.58×10 12/L, hemoglobin (HB) was 101 g/L, and platelet count (PLT) was 202×10 9/L. On day 2 of medication, his blood cell count began to decrease, with the lowest values of WBC 2.96×10 9/L, RBC 2.40×10 12/L, Hb 66 g/L, and PLT 128×10 9/L, respectively. It was misdiagnosed as gastrointestinal bleeding because of positive occult blood in gastric juice of the patient at the same time. However, the patient had no obvious melena, his gastric fluid occult blood did not match the development of anemia, and there was no evidence of hemolysis or hemorrhage at other sites. The relationship between the blood cell count decrease and piperacillin sodium and tazobactam sodium was considered. The drug was discontinued and the patient′s blood cell count returned to levels before treatment 3 days later.
