Sitagliptin phosphate-induced bullous pemphigoid
10.3760/cma.j.cn114015-20200113-00040
- VernacularTitle:磷酸西格列汀致大疱性类天疱疮
- Author:
Shaoying YANG
1
;
Bin WANG
;
Linyu FU
;
Chunping ZHANG
Author Information
1. 海南省文昌市人民医院药学部，文昌 571321；海南医学院第一附属医院药学部，海口 570102
- Publication Type:Journal Article
- Keywords:
Sitagliptin phosphate;
Pemphigoid, bullous;
Diabetes mellitus
- From:
Adverse Drug Reactions Journal
2020;22(11):652-653
- CountryChina
- Language:Chinese
-
Abstract:
A 70-year-old male patient with type 2 diabetes mellitus was treated with sitagliptin phosphate (sitagliptin) on the basis of previous oral metformin hydrochloride due to poor glycemic control. After 16 days of medication, the patient developed erythema and blisters with itching on the skin of the limbs. Laboratory tests showed that the white blood cell count was 12.2×10 9/L, neutrophil count was 8.5×10 9/L, and eosinophil count was 4.56×10 9/L. Histopathological examination of the skin lesion showed blisters under the epidermis, intact epidermis at the top of the blisters, dermal papillae at the bottom of the blisters, serous fluid and eosinophils in the blisters, and slight infiltration of eosinophils in the superficial dermis under the blisters. Bullous pemphigoid was diagnosed, which was considered to be related to sitagliptin. Therefore, the drug was discontinued. One week later, erythema and blisters gradually disappeared and no erythema or blisters recured.
