Bronchial asthma due to zoledronic acid injection
10.3760/cma.j.cn114015-20200119-00054
- VernacularTitle:唑来膦酸注射液诱发支气管哮喘
- Author:
Lei GAO
1
;
Man LI
;
Jun CAI
;
Wenxia CUI
;
Yun HU
Author Information
1. 南京大学医学院附属鼓楼医院老年科，南京 210008
- Publication Type:Journal Article
- Keywords:
Zoledronic acid;
Osteoporosis;
Asthma
- From:
Adverse Drug Reactions Journal
2020;22(11):656-657
- CountryChina
- Language:Chinese
-
Abstract:
A 77-year-old female patient received an intravenous infusion of zoledronic acid injection 5 mg for osteoporosis. The patient had a history of asthma and no asthma attacks before medication. Nineteen hours after the intravenous infusion of zoledronic acid injection, the patient developed asthma, dyspnea, and wheezing in both lungs. Bronchial asthma attack was diagnosed, which was considered to be induced by zoledronic acid injection. An IV infusion of methylprednisolone, venous pumping of doxofylline, and aerosol inhalation of salbutamol, ipratropium bromide, and budesonide for inhalation were given immediately. Thirty minutes later, her symptoms of asthma and dyspnea were relieved. Twenty-six hours later, bronchial asthma recurred and was improved again after the above treatments. However, the patient′s exercise tolerance decreased. After 3 months of treatments with inhalation of budesonide and formoterol fumarate powder for inhalation and oral administration of montelukast, her exercise tolerance returned as before zoledronic acid injection.
