Severe thrombocytopenia induced by imipenem and cilastatin sodium
10.3760/cma.j.cn114015-20200223-00157
- VernacularTitle:亚胺培南西司他丁钠致严重血小板减少
- Author:
Yongchun YU
1
;
Daiquan GAO
Author Information
1. 西藏自治区拉萨市人民医院医疗保健科，拉萨 850000
- Publication Type:Journal Article
- Keywords:
Imipenem;
Cilastatin;
Thrombocytopenia;
Drug-related side effects and adverse reactions
- From:
Adverse Drug Reactions Journal
2020;22(11):654-655
- CountryChina
- Language:Chinese
-
Abstract:
A 76-year-old male patient with unstable angina pectoris switched to an IV infusion of imipenem and cilastatin sodium 1.0 g once every 8 hours because of the ineffective treatment of pneumonia with amoxicillin and clavulanate potassium combined with levofloxacin. The platelet count (PLT) was 109×10 9/L before treatment. After 9 days of medication, the patient′s symptoms of cough and dyspnea were improved, his body temperature returned to normal, but he developed skin petechiae, accompanied by a small amount of epistaxis and hematuria. At the same time, his PLT was 0. Imipenem and cilastatin sodium was immediately discontinued, recombinant human thrombopoietin combined with methylpredniso- lone and human immunoglobulin were given, the patient′s PLT gradually increased and the bleeding symptoms disappeared. Ten days later, his PLT was 173×10 9/L. It is suggested that high-dose imipenem and cilastatin sodium should be used cautiously in elderly patients and the monitoring should be strengthened during the treatment.
