Research Progress on Antitumor Effects of Usnic Acid
10.3870/j.issn.1004-0781.2025.04.019
- VernacularTitle:松萝酸抗肿瘤作用研究进展
- Author:
Shanshan HU
1
;
Yayun LIU
1
;
Deqiao SHENG
1
;
Yi YANG
1
Author Information
1. 肿瘤微环境与免疫治疗湖北省重点实验室,三峡大学基础医学院,宜昌 443002
- Publication Type:Journal Article
- Keywords:
Usnic acid;
Usnic acid analogues;
Antitumor effect
- From:
Herald of Medicine
2025;44(4):619-627
- CountryChina
- Language:Chinese
-
Abstract:
Usnic acid,a secondary metabolite derived from lichens,has been extensively utilized in pharmaceuticals,dietary supplements,and various daily chemical products,including feed,dye,food,perfume and cosmetics,due to its notable pharmacological effects,including anti-tumor,antibacterial,antiviral,and anti-inflammatory properties.Recent studies have shown that usnic acid can inhibit the occurrence and progression of various tumors through inducing apoptosis and autophagy,arresting cell cycle progression,inhibiting cell migration and invasion,and regulating the expression of microRNAs(miRNAs).Furthermore,usnic acid can be combined with clinical anticancer drugs to achieve synergistic anti-cancer effects.Additionally,modified usnic acid analogues also exhibit significant anti-tumor activity.This article will focus on the current research status of usnic acid,examining its physical and chemical properties,the mechanisms underlying its anti-tumor effects,and the anti-tumor activity of its analogues.
