Autoimmune hypoglycemia due to alpha thioctic acid injection
10.3760/cma.j.cn114015-20190920-00777
- VernacularTitle:α-硫辛酸注射液致自身免疫性低血糖症
- Author:
Tao CHEN
1
;
Lihua HUANG
;
Xiaoyan XING
;
Xiaomu KONG
;
Mei TU
Author Information
1. 福建医科大学附属龙岩第一医院内分泌科，龙岩 364000
- Publication Type:Journal Article
- Keywords:
Thioctic acid;
Autoimmune diseases;
Hypoglycemia
- From:
Adverse Drug Reactions Journal
2020;22(10):577-578
- CountryChina
- Language:Chinese
-
Abstract:
A 69-year-old female patient with type 2 diabetes mellitus received an IV infusion of alpha thioctic acid injection 0.6 g dissolved in 0.9% sodium chloride injection 250 ml for peripheral neuropathy. Eighteen hours after drug withdrawal, the patient had a sudden cold sweat with fatigue, dizziness, and hunger at night. After that, the patient repeatedly had paroxysmal cold sweat with dizziness and fatigue at night, which could be relieved after eating. The peripheral blood glucose at onset of symptoms was 2.1 mmol/L. Laboratory tests showed that fasting insulin was more than 6 945 pmol/L, insulin autoantibody was positive, and insulin release index was more than 29.00. The patient was diagnosed as having autoimmune hypoglycemia, which was considered to be related to alpha thioctic acid injection. Prednisone acetate 10 mg was given orally, thrice daily. Her symptoms of hypoglycemia were relieved 3 days later and disappeared 5 days later. Thereafter, prednisone acetate dose was gradually reduced to 1.25 mg/d and stopped about one year and 7 months later. During the treatment, her insulin autoantibody turned negative, serum insulin returned to normal, and hypoglycemia did not recur.
