Oxaliplatin-induced sensorineural deafness and acute optic neuritis
10.3760/cma.j.cn114015-20191211-01013
- VernacularTitle:奥沙利铂致感音神经性耳聋和急性视神经炎
- Author:
Wei WU
1
;
Binbin CHU
1
;
Linchun LIANG
1
Author Information
1. 浙江大学明州医院肿瘤内科，宁波 315100
- Publication Type:Journal Article
- Keywords:
Oxaliplatin;
Hearing loss, sensorineural;
Optic neuritis
- From:
Adverse Drug Reactions Journal
2020;22(10):599-600
- CountryChina
- Language:Chinese
-
Abstract:
A 59-year-old male patient received SOX chemotherapy regimen (IV infusion of oxaliplatin injection 200 mg dissolved in 5% glucose injection 250 ml for 2 hours on the first day, oral tegafur, gimeracil and oteracil potassium 60 mg once daily on day 1-14, every 3 weeks was a cycle) for gastric cancer with multiple lymph nodes metastases. One week after the infusion of oxaliplatin during the third cycle, the patient suddenly developed deafness and blurred vision. The patient was diagnosed with sudden sensorineural deafness and acute optic neuritis after otorhinolaryngologist consultation. His sudden sensorineural deafness and acute optic neuritis were considered to be associated with oxaliplatin. Chemotherapy was discontinued and the patient was given neurotrophic and microcirculation-improving medications. One 1 week later, the patient′s vision gradually returned to normal, but the deafness persisted.
