Effect of remimazolam on recovery quality of children with strabismus surgery under general anesthesia
- VernacularTitle:瑞马唑仑对全麻下斜视手术患儿苏醒质量的影响
- Author:
Yan MIAO
1
;
Lei ZHU
;
Yuanhui FAN
Author Information
- Publication Type:Journal Article
- Keywords: benzodiazepines; strabismus; emergence delirium; hemodynamics; propofol; child; remimazolam
- From: Tianjin Medical Journal 2025;53(4):425-428
- CountryChina
- Language:Chinese
- Abstract: Objective To compare the effects of remimazolam and propofol on the quality of recovery in children with strabismus surgery under general anesthesia.Methods A total of 100 children scheduled for strabismus surgery were enrolled and randomly assigned to the remimazolam group(R group)or the propofol group(P group).Children in the R group received intravenous remimazolam 0.2 mg/kg,followed by remimazolam infusion at a rate of 1-3 mg·kg-1·h-1.Children in the P group received intravenous propofol 2.5 mg/kg,followed by propofol infusion at a rate of 4-12 mg·kg-1·h-1.The intraoperative hypotension,extubation time,post-anesthesia care unit(PACU)stay time,postoperative nausea and vomiting(PONV),and incidence of emergence agitation were recorded in the two groups of patients.Emergence agitation was assessed using the Pediatric Anesthesia Emergence Delirium(PAED)scale.Results A total of 49 and 50 children were included in the R group and the P group,respectively.Compared with the P group,the R group showed a significant increase in mean arterial pressure and heart rate at 15 minutes after the start of surgery(P<0.05).The incidence of intraoperative hypotension(14.3%vs.46.0%)and emergence agitation(14.3%vs.38.0%)were significantly lower in the R group than those in the P group(P<0.05).The extubation time[(15.7±5.8)min vs.(11.3±4.6)min],PACU stay time[(27.5±7.3)min vs.(23.2±6.5)min]were significantly longer in the R group than those in the P group,while the highest PAED score[(7.6±2.9)vs.(9.4±3.3)]was significantly lower in the R group than that in the P group,(P<0.05).Conclusion Compared with propofol,remimazolam can reduce the risk of emergence agitation in children undergoing strabismus surgery under general anesthesia,and has advantages in maintaining hemodynamic stability during surgery.
