Diagnostic value of serum sST2 and DcR3 combined with dynamic electrocardiogram in silent myocardial ischemia
- VernacularTitle:血清sST2、DcR3联合动态心电图对无症状性心肌缺血的诊断价值
- Author:
Yehang ZHANG
1
;
Xiangdong NIU
1
;
Yiming GENG
1
Author Information
- Publication Type:Journal Article
- Keywords: myocardial ischemia; electrocardiography,ambulatory; soluble growth stimulation expressed gene 2; decoy receptor 3; dynamic electrocardiogram; asymptomatic myocardial ischemia
- From: Tianjin Medical Journal 2025;53(4):420-424
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the diagnostic value of serum soluble growth stimulation expressed gene 2(sST2),decoy receptor 3(DcR3)and dynamic electrocardiogram(DCG)for asymptomatic myocardial ischemia(SMI).Methods Eighty-five patients with coronary heart disease were selected as observation subjects(the observation group).Sixty-one SMI patients were confirmed by coronary angiography(the SMI group).Among them,there were 24 cases with symptomatic myocardial ischemia(the symptomatic myocardial ischemia group).During the same period,84 patients with unexplained chest pain who were examined in our hospital and without coronary heart disease were selected as the control group.ELISA was applied to detect serum levels of sST2 and DcR3.ROC was used to analyze the diagnostic value of serum sST2,DcR3 and DCG for SMI.Multivariate Logistic regression was applied to analyze the influencing factors of SMI.Results The serum level of sST2 was higher in the observation group than that in the control group[(55.61±7.12)μg/L vs.(14.22±3.64)μg/L],while the level of DcR3 was lower than that in the control group[(0.68±0.11)μg/L vs.(1.24±0.21)μg/L](P＜0.05).The serum level of sST2 was higher in the SMI group than that in the symptomatic myocardial ischemia group[(59.28±7.12)μg/L vs.(46.28±8.15)μg/L],while the level of DcR3 was lower than that in the symptomatic myocardial ischemia group[(0.63±0.11)μg/L vs.(0.81±0.14)μg/L](P＜0.05).The heart rate of the SMI group was higher than that of the symptomatic myocardial ischemia group,and the duration of ischemia and the decrease in ST segment were lower than those of the symptomatic myocardial ischemia group(P＜0.05).ROC curve results showed that the AUC values of serum sST2,DcR3 and DCG alone and in their combination for diagnosing SMI in patients with coronary heart disease were 0.826,0.882,0.773,and 0.958,respectively,and the combined diagnosis of SMI was superior to individual diagnosis(Z=3.188,2.225,2.770,P＜0.05).sST2 and DcR3 were influencing factors of SMI occurrence(P＜0.05).Conclusion The increased serum sST2 and the decreased DcR3 are closely related to the occurrence of SMI,and the combination of serum sST2 and DcR3 with DCG has certain diagnostic value for SMI.
