Research progress of oxidative stress and antioxidants in acute pancreatitis
- VernacularTitle:氧化应激及抗氧化剂在急性胰腺炎中的研究进展
- Author:
Yangjuan DING
1
;
Shihai XIA
;
Wei XU
;
Qinghong GAO
;
Taotao LIU
Author Information
- Publication Type:Journal Article
- Keywords: pancreatitis,acute necrotizing; oxidative stress; antioxidants; inflammation
- From: Tianjin Medical Journal 2025;53(4):444-448
- CountryChina
- Language:Chinese
- Abstract: Acute pancreatitis(AP),one of the most common acute abdominal conditions in clinical practice,is typically self-limiting.However,approximately 20%of cases progress to severe acute pancreatitis,characterized by persistent systemic inflammatory response syndrome and multiple-organ dysfunction syndrome,with a high mortality rates.The pathogenesis of AP involves complex pathophysiological processes,and in recent years,the role of oxidative stress(OS)in AP has garnered increasing attention.OS refers to an imbalance between reactive oxygen species production and antioxidant capacity following endogenous or exogenous stimuli,which can lead to pancreatic cell injury,exacerbation of inflammatory responses,and organ dysfunction.Notably,antioxidants have demonstrated efficacy in reducing OS-induced pancreatic damage and multi-organ dysfunction in animal models.This article reviews current molecular mechanisms of OS in AP,its role in disease progression and recent advances in antioxidant-based therapeutic strategies for AP.
