Acute lung injury and respiratory failure induced by paroxetine overdose
10.3760/cma.j.cn114015-20200229-00188
- VernacularTitle:帕罗西汀过量致急性肺损伤和呼吸衰竭
- Author:
Xu DONG
1
;
Yanbo LAI
;
Tao FENG
Author Information
1. 宁夏回族自治区第三人民医院重症医学科，银川 750011
- Publication Type:Journal Article
- Keywords:
Paroxetine;
Depressive disorder;
Drug overdose;
Acute lung injury
- From:
Adverse Drug Reactions Journal
2020;22(12):703-704
- CountryChina
- Language:Chinese
-
Abstract:
A 32-year-old female patient received long-term use of paroxetine 40 mg/d orally for depression. Because of uncontrolled behavior, the patient took paroxetine about 1 000 mg at one time. About 24 hours after taking the medicine, the patient developed cough and expectoration, followed by dyspnea, and 2 days later, the patient became unconscious. The partial pressure of oxygen was 38 mmHg, and the partial pressure of carbon dioxide was 43 mmHg. Chest CT showed ground glass opacities in bilateral lungs, indicating interstitial pulmonary edema. Acute lung injury and respiratory failure were diagnosed. Then mechanical ventilation via a tracheal cannula, continuous intravenous pumping of methylprednisolone 160 mg/d, and symptomatic treatments such as anti-infection, fluid infusion, correction of acid-base imbalance were given. Her respiratory condition was gradually improved, and the partial pressure of oxygen gradually returned to normal; 5 days later, the ventilator was stopped and the tracheal tube was removed.
