Application of Circular RNA in Diagnosis and Treatment of Tumor
10.13865/j.cnki.cjbmb.2025.01.1288
- VernacularTitle:环状RNA在肿瘤诊疗中的应用
- Author:
Yi YANG
1
;
Song-Ying OUYANG
1
;
Jun-Jun WU
1
Author Information
1. 福建师范大学生命科学学院生物科学系,福州 350117
- Publication Type:Journal Article
- Keywords:
circular RNA(circRNA);
biomarker;
disease diagnosis;
vaccine;
immunotherapy
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(3):344-352
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA(circRNA)is a single-stranded RNA with a covalently closed loop structure,which has a more stable structure and lower immunogenicity than linear RNA.Many studies have shown that circRNA has characteristics such as conservation,stability,and tissue specificity,and can act as a microRNA(miRNA)sponge to interact with proteins and translation templates,and regulate biological functions such as gene expression and signal transduction.Based on the characteristics and various bio-logical functions of circRNA,some endogenous circRNA plays an important regulatory role in the occur-rence and development of tumors and has the potential to be used as biomarkers and therapeutic targets.In addition,mRNA drugs have limitations such as instability,easy degradation,low translation efficien-cy,and immunogenicity in practical applications.Engineered translatable exogenous circRNA can solve some of the limitations of linear mRNA application and become a new type of potential efficient drug.In this paper,we introduce the circRNA biogenesis mechanisms,specific biological functions,and the cur-rent status of diagnosis and treatment applications in tumors.This includes the diagnostic application of endogenous circRNA in tumors,the design and synthesis strategies of exogenous circRNA,and the cur-rent progress in the design and application of engineered circRNA vaccines using their stable and efficient protein expression functions in the treatment of tumors.Finally,we discuss the current clinical diagnostic application problems of circRNA,the challenges of exogenous circRNA therapeutic applications,and the prospects of the field.
