Protein Kinase CK2:Regulation of Aging and Aging-related Diseases
10.13865/j.cnki.cjbmb.2025.02.1384
- VernacularTitle:酪蛋白激酶Ⅱ:衰老与衰老相关疾病调控
- Author:
Rui-Qi WANG
1
;
Jie-Liang YANG
1
;
Zi-Mei WANG
1
Author Information
1. 广东市基因组稳定性与人类疾病预防重点实验室,广东 深圳 518055;深圳市抗衰老与再生重点实验室,深圳市卡尔森国际肿瘤重点实验室,深圳大学医学部基础医学院,广东 深圳 518055
- Publication Type:Journal Article
- Keywords:
casein kinase 2(CK2);
aging;
cellular senescence;
aging-related diseases
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(3):333-343
- CountryChina
- Language:Chinese
-
Abstract:
Aging is the result of the accumulation of various molecular and cellular damages over time,encompassing 12 characteristic hallmarks divided into three categories.These include primary hallmarks such as genomic instability,telomere attrition,epigenetic alterations,loss of proteostasis,and disabled macroautophagy;antagonistic hallmarks like deregulated nutrient sensing,mitochondrial dysfunction,and cellular senescence;and integrative hallmarks including stem cell exhaustion,altered intercellular com-munication,chronic inflammation and dysbiosis.Therefore,investigating cellular signaling factors within a single pathway is insufficient to comprehensively understand the complex mechanisms underlying aging.Casein kinase Ⅱ(CK2),one of the earliest identified protein kinases,is capable of phosphorylating ser-ine/threonine/tyrosine residues on hundreds of substrates.It exhibits highly constitutive expression and activity,and is extensively involved in the regulation of cellular processes such as proliferation,differenti-ation,apoptosis,stress response,metabolism,and immune function.CK2 plays a unique role in coordi-nating the cross-talk and integration of various signaling pathways,which is crucial for maintaining cell survival and homeostasis.Recent studies have revealed that CK2 exhibits perturbations in both expression levels and enzymatic activity during aging process,with notable heterogeneity observed across different animals,tissues and cellular models.Overall,the downregulation of CK2 expression not only promotes the development of primary hallmarks but also alleviates antagonistic hallmarks and ameliorates integrative hallmarks of aging,demonstrating dual effect and interconnected mechanisms.Notably,aberrant activa-tion in CK2 expression and activity are associated with various aging-related diseases,including cancer,cardiovascular diseases,chronic metabolic disorders,neurodegenerative diseases and skeletal degenera-tive conditions.Therefore,maintaining CK2 homeostasis may represent an effective strategy for delaying aging.This review summarizes the latest advances in CK2 and aging research,providing not only deeper insights into the common mechanisms underlying aging and aging-related diseases,but also a theoretical foundation for identifying potential targets for the early prevention of aging-related diseases.
