Mental disorders caused by an interaction of oxycodone and pregabalin
10.3760/cma.j.cn114015-20200218-00132
- VernacularTitle:羟考酮与普瑞巴林相互作用致精神异常
- Author:
Nan ZHOU
1
;
Guiping GUO
;
Lichao MAO
;
Yue GUAN
Author Information
1. 陕西省人民医院药学部，西安 710068
- Publication Type:Journal Article
- Keywords:
Oxycodone;
Pregabalin;
Cognitive impairment;
Mental disorders;
Drug interactions
- From:
Adverse Drug Reactions Journal
2020;22(10):597-598
- CountryChina
- Language:Chinese
-
Abstract:
A 51-year-old male patient received an operation treatment for paranasal sinusitis induced by radiotherapy and chemotherapy of nasopharyngeal carcinoma. One oxycodone and acetaminophen tablet (each tablet contains oxycodone hydrochloride 5 mg and acetaminophen 325 mg) was given orally thrice daily before and after the operation. Pregabalin 75 mg twice daily was added because of the poor analgesic effectiveness. During the treatment, oral oxycodone hydrochloride 10 mg was given once daily by his family members for 2 days. Two days after the addition of pregabalin, the patient developed mental disorders, such as delirium, irritability, involuntary convulsions of limbs, cognitive impairment, and disorientation. All above-mentioned analgesics were discontinued and dexmedetomidine was given for pain relief and sedation. Three days later, the mental state of the patient was improved, there was no obvious delirium, the discrimination and orientation returned to normal, and dexmetomidine was discontinued. There was an obvious time correlation between the occurrence and disappearance of mental disorders and the combination of analgesic drugs. Referring to the previous literature, it was considered that the mental disorders of the patient were caused by the interaction between oxycodone and pregabalin.
