The correlation between serum Apelin,IGF-2 and GLUT1 levels with tumor proliferation and recurrence in children with hemangioma
- VernacularTitle:血管瘤患儿血清Apelin、IGF-2、GLUT1水平与瘤体增生及复发的关系
- Author:
Taoran YAN
1
;
Yu TIAN
1
;
Xuesong GUO
1
Author Information
- Publication Type:Journal Article
- Keywords: hemangioma; Apelin; insulin-like growth factor Ⅱ; glucose transporter type 1; propranolol; recurrence
- From: Tianjin Medical Journal 2025;53(4):378-382
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the relationship between serum endogenous ligand(Apelin),insulin-like growth factor-2(IGF-2)glucose transporter 1(GLUT1)and tumor hyperplasia and recurrence after withdrawal propranolol in infantile hemangioma(IH)children.Methods A total of 126 IH patients were selected and divided into the proliferative phase group(74 cases)and the involuting phase group(52 cases)based on the pathological results.Meanwhile,56 patients with vascular malformations were selected as the vascular malformation group.Enzyme-linked immunosorbent assay(ELISA)was used to detect the serum levels of Apelin,IGF-2 and GLUT1 on the day after admission.All IH patients were treated with propranolol for 3 months.According to the follow-up results,IH patients were divided into the recurrence group(43 cases)and the non-recurrence group(83 cases).Serum levels of Apelin,IGF-2 and GLUT1 were compared between different groups of patients.Multivariate Logistic regression analysis was used to analyze risk factors for recurrence after propranolol discontinuation in IH patients.The prediction value of serum Apelin,IGF-2 and GLUT1 levels for recurrence after propranolol discontinuation in IH patients was analyzed by receiver operating characteristic curve(ROC).Results Compared with the vascular malformation group,serum levels of Apelin,IGF-2 and GLUT1were increased in the IH group(P<0.05).Compared with the degenerative group,serum levels of Apelin,IGF-2 and GLUT1 were increased in the proliferative group(P<0.05).Serum levels of Apelin,IGF-2 and GLUT1 were significantly higher in the recurrence group than those in the non-recurrence group(P<0.05).The increased Apelin,IGF-2 and GLUT1,and hemangioma grade Ⅰ-Ⅱ after treatment were independent risk factors for recurrence after withdrawal of propranolol in children with IH(P<0.05).The area under the curve(AUC)of Apelin,IGF-2 and GLUT1 combined predicted IH recurrence was better than that of simple prediction(P<0.05).Conclusion The increased serum levels of Apelin,IGF-2 and GLUT1 in IH patients can be used as serum indicators to predict tumor hyperplasia and recurrence after propranolol withdrawal in patients.
