Driver Genes in Hepatocellular Carcinoma
10.13865/j.cnki.cjbmb.2024.12.1141
- VernacularTitle:肝细胞癌治疗的新视角:驱动基因的研究
- Author:
Che CHEN
1
;
Xu ZHANG
1
;
Ya-Zhen SU
1
Author Information
1. 甘肃中医药大学公共卫生学院,兰州 730000
- Publication Type:Journal Article
- Keywords:
driver gene;
hepatocellular carcinoma(HCC);
telomeres;
cell cycle;
epigenetics
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(3):376-383
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths,and al-though considerable progress has been made in the clinical diagnosis and treatment of HCC,the prognosis for patients remains poor,with a 5-year survival rate of only about 18％.The development of HCC is driven by the occurrence of mutations in driver genes that can directly promote cell proliferation,survival and metastasis.With the development of molecular biology and genomics technologies,researchers have elucidated that driver mutations that give HCC cells a selective growth advantage,the ability of the cells to resist apoptosis,maintain proliferative signals,initiate invasion and metastasis,induce angiogenesis,enable metabolic remodeling and immune escape.Exploring the key drivers of HCC development to fur-ther elucidate the pathogenesis of HCC may provide new directions for the diagnosis and treatment of HCC as well as improving the prognosis.In this paper,we summarize the driver gene mutations in HCC from various biological pathways such as telomere maintenance,cell cycle,the Wnt signaling pathway,oxida-tive stress,and epigenetic modifications.We also summarize the application prospects of driver gene mu-tations in the diagnosis and treatment of HCC.We aim to provide a reference for the diagnosis,treatment and research of HCC.
