Severe electrolyte disorders and rhabdomyolysis caused by long-term use of capreomycin
10.3760/cma.j.issn.1008-5734.2020.01.010
- VernacularTitle:长期应用卷曲霉素致严重电解质紊乱和横纹肌溶解症
- Author:
Lingyan GAO
1
;
Yue WANG
;
Yuling LIU
;
Ang DENG
Author Information
1. 航天中心医院药剂科，北京 100049；中日友好医院药学部，北京 100029
- Publication Type:Journal Article
- Keywords:
Capreomycin;
Hypokalemia;
Hypocalcemia;
Rhabdomyolysis
- From:
Adverse Drug Reactions Journal
2020;22(1):44-45
- CountryChina
- Language:Chinese
-
Abstract:
A 53-year-old female patient received oral ethambutol, pyrazinamide, isoniazid, and moxifloxacin, as well as intramuscular injection of capreomycin for drug-resistant tuberculosis. After 11 months of treatments, the patient developed nausea, vomiting, fatigue, weakness of limbs, gradually aggravating with soft paralysis of both legs. Laboratory tests showed the lowest values of serum potassium, sodium, calcium, phosphorus, and magnesium were 1.3, 128, 1.44, 0.20 and 0.38 mmol/L, respectively and creatine kinase (CK) increased to 13 517 U/L. The patient was diagnosed with electrolyte disorder and rhabdomyolysis. After 14 days of treatments with intravenous and oral supplementation of potassium, magnesium, calcium, and phosphorus, as well as oral spironolactone, the levels of serum potassium, sodium, calcium, phosphorus, and magnesium were 4.1, 141, 2.31, 1.13, and 0.67 mmol/L, respectively. The patient′s muscle strength recovered well and the patient could walk autonomously.
