Research progress of polymyxin B-associated skin hyperpigmentation
10.3760/cma.j.issn.1008-5734.2020.01.008
- VernacularTitle:多粘菌素B相关皮肤色素沉着的研究进展
- Author:
Shaonan ZHANG
1
;
Xiaohui HUANG
;
Huijie YUE
Author Information
1. 东部战区总医院药理科，南京 210002；安徽省芜湖市第二人民医院药剂科 241000
- Publication Type:Journal Article
- Keywords:
Polymyxin B;
Skin pigmentation;
Hyperpigmentation
- From:
Adverse Drug Reactions Journal
2020;22(1):38-41
- CountryChina
- Language:Chinese
-
Abstract:
Polymyxin B is mainly used in the treatment of severe drug-resistant gram-negative bacterial infection. In recent years, more and more cases of skin pigmentation caused by polymyxin B have been reported. The incidence of polymyxin B-related skin pigmentation in infants was higher than that in adults. The mechanism of polymyxin B-induced hyperpigmentation is not clear, which may be related to histamine release, skin inflammation, and the stimulation of melanin synthesis induced by polymyxin B. Although skin pigmentation has no significant effect on the treatment and prognosis in patients, it may cause psychological burden and affect the life quality, which should be paid more attention to and further studied.
