Interstitial pneumonia due to oxaliplatin
10.3760/cma.j.cn114015-20190708-00548
- VernacularTitle:奥沙利铂致间质性肺炎
- Author:
Xiaoyan LU
1
;
Youqin DAI
;
Yamiao WU
;
Sijia YANG
;
Junyong ZOU
;
Wei CHEN
Author Information
1. 中国科学院大学宁波华美医院药学部 315010
- Publication Type:Journal Article
- Keywords:
Oxaliplatin;
Lung diseases, interstitial;
Drug toxicity
- From:
Adverse Drug Reactions Journal
2020;22(9):550-552
- CountryChina
- Language:Chinese
-
Abstract:
A 64-year-old male patient with colon cancer received one cycle chemotherapy of oxaliplatin+capecitabine and 7 cycles of oxaliplatin+raltitrexed chemotherapy. There were no interstitial changes in chest CT before operation. After 8 cycles of chemotherapy, the patient developed chest tightness and shortness of breath. Chest CT showed interstitial changes in bilateral lungs, which were considered to be related to oxaliplatin. After 31 days of treatments with drugs such as broad-spectrum antibiotics, glucocorticoids, acetylcysteine, and reduced glutathione, as well as noninvasive ventilator assisted ventilation, oxygen inhalation, and other symptomatic treatments, his symptoms of chest tightness and shortness of breath were relieved, and chest CT showed that interstitial lesions in the bilateral lungs were obviously relieved.
