QT interval prolongation caused by concomitant use of moxifloxacin hydrochloride injection and amiodarone hydrochloride for injection
10.3760/cma.j.issn.1008-5734.2020.01.009
- VernacularTitle:盐酸莫西沙星注射液与注射用盐酸胺碘酮联用致QT间期延长
- Author:
Anqin ZHOU
1
;
Min LUO
;
Dengliang ZHANG
;
Ting XU
Author Information
1. 西南医科大学附属中医医院临床药学办公室，四川省泸州市 646000
- Publication Type:Journal Article
- Keywords:
Moxifloxacin;
Amiodarone;
Long QT syndrome
- From:
Adverse Drug Reactions Journal
2020;22(1):42-43
- CountryChina
- Language:Chinese
-
Abstract:
A 75-year-old male received an IV infusion of moxifloxacin hydrochloride injection (moxifloxacin) 400 mg/d once daily for valvular heart disease complicated with heart failure and pulmonary infection. On the second day, the electrocardiogram showed that the corrected QT interval (QTc) was prolonged from 455 ms before treatment to 490 ms. On the third day, amiodarone hydrochloride for injection (amiodarone) 150 mg was given by slow intravenous injection in the early morning due to atrial fibrillation and 300 mg of amiodarone was continuously pumped at the speed of 30 mg/h at noon. In the afternoon of the 4th day, amiodarone 300 mg was given again via a pump at a speed of 30 mg/h. About 20 minutes later,the QTc was prolonged to 607 ms. On the 5th day, amiodarone was not given again, but the QTc continued to be prolonged up to 674 ms. On the 6th day, the QTc gradually returned to be within the normal range after discontinuation of moxifloxacin. The prolongation of QT interval in the patient was considered to be associated with moxifloxacin and amiodarone.
