Parkinson-like symptoms induced by lappaconitine hydrobromide for injection
10.3760/cma.j.issn.1008-5734.2020.01.013
- VernacularTitle:注射用氢溴酸高乌甲素致帕金森样综合征
- Author:
Huabo WEI
1
;
Cheng SHU
;
Lan LI
;
Yang DONG
Author Information
1. 重庆市丰都县人民医院药剂科 408200
- Publication Type:Journal Article
- Keywords:
Alkaloids;
Aconitine;
Fasciculation;
Parkinsonian disorders;
Lappaconitine
- From:
Adverse Drug Reactions Journal
2020;22(1):50-51
- CountryChina
- Language:Chinese
-
Abstract:
A 75-year-old male patient received an IV infusion of lappaconitine hydrobromide for injection 4 mg dissolved into 5% glucose injection 250 ml once daily due to bone metastases of lung cancer. After a single time of lappaconitine treatment, the patient developed muscle tremor mainly in the limbs, which was obvious in the sitting and standing positions and disappeared after lying flat. After 2 times of lappaconitine treatment, the muscle tremor was aggravated and he was unable to take care of himself due to tremor, showing that his hands could not hold things and walking was difficult. No other abnormal signs were found except the increase of muscle tension. The extrapyramidal symptoms (Parkinson-like symptoms) induced by lappaconitine was considered. Then lappaconitine was stopped and other treatments continued. About 24 hours of lappaconitine withdrawal, the patient′s muscle tremor disappeared. After 8 days of observation, his symptoms did not recur.
