Event-related potential study on cognitive function in children with obstructive sleep apnea
10.3760/cma.j.cn371468-20240716-00334
- VernacularTitle:阻塞性睡眠呼吸暂停儿童认知功能的事件相关电位研究
- Author:
Ya ZHANG
1
;
Yunxiao WU
;
Yingchao JIANG
;
Li ZHENG
;
Zhifei XU
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院，国家呼吸系统疾病临床医学研究中心临床部一病区，北京 100045
- Publication Type:Journal Article
- Keywords:
Obstructive sleep apnea;
Sleep disordered breathing;
Children;
Cognitive;
Event-related potentials
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2025;34(4):334-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes in N100, P300, and N400 of event-related potential(ERP) in children with obstructive sleep apnea (OSA), and provide the basis for evaluating cognitive and neurological impairment in pediatric OSA.Methods:Totally 108 children aged 5-10 years who visited the Sleep Center of Beijing Children's Hospital due to snoring or mouth breathing were recruited from June to September, 2023, and ultimately 90 children were included in the study.According to the obstructive sleep apnea hypopnea index (OAHI) in their polysomnography (PSG) results, children with OAHI>1 time/h were classified as OSA group ( n=74), and children with OAHI ≤ 1 time/h were classified as non-OSA group ( n=16).All participants completed the auditory oddball and Peabody image vocabulary test tasks, and the EEG data collected through ERP technology were compared between the two groups.SPSS 26.0 software was used for statistical analysis, and independent samples t-test or non parametric test was used for comparison between the two groups. Results:The P300 latency of OSA children in lead Fz was significantly longer than that of non OSA children (330.00(308.00, 396.00) ms, 309.00(294.50, 337.50)ms), and the difference was statistically significant ( Z=-2.143, P=0.032). The latency of P300 was positively correlated with apnea hypopnea index(AHI)(Fz lead: r=0.332, Cz lead: r=0.239, Pz lead: r=0.213, all P<0.05). There was no statistically significant difference in P300 latency between Cz and Pz leads ( Z=-1.615, P=0.106; Z=-1.055, P=0.291). There was no statistically significant difference in the amplitude of P300 among the leads (all P>0.05). There was no statistically significant difference in the amplitude and latency of N100 and N400 (both P>0.05). Conclusion:The latency of P300 in OSA children is significantly longer than that in non-OSA children, indicating impaired cognitive function. The latency of auditory P300 might serve as an early neuroelectrophysiological biomarker for identifying cognitive impairment in OSA children.
