Abnormalities of cerebellar-cerebral circuits and social impairment in ASD
10.3760/cma.j.cn371468-20240626-00296
- VernacularTitle:小脑-大脑环路异常与ASD社交障碍
- Author:
Wenjing HU
1
;
Tingli HE
;
Zhe ZHANG
;
Hongyan XU
;
Zhangying ZHOU
;
Xinxin CUI
;
Danmeng CHENG
;
Yanan HAN
;
Xianwen DONG
;
Anqin DONG
Author Information
1. 郑州大学第五附属医院，河南省康复医学重点实验室河南省康复临床医学研究中心，郑州 450052
- Publication Type:Journal Article
- Keywords:
Cerebellar-cerebral circuits;
Cerebellum;
Autism spectrum disorders;
Social impairment;
Noninvasive brain stimulation
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2025;34(4):328-333
- CountryChina
- Language:Chinese
-
Abstract:
Autism spectrum disorder(ASD) is a neurodevelopmental disorder, and social impairment was one of the core symptoms of ASD, which can seriously affects the social life of patients.The pathogenesis of social impairment in ASD is unclear and it may involves many brain abnormalities.The related theories and hypotheses are numerous and there is no unified conclusion. Studies have shown that the cerebellum has extensive connections with brain networks and is involved in the regulation of social cognition, but its role in ASD has not been fully emphasized.The structural and functional abnormalities of the cerebellar-cortex (CC) loop in ASD patients can lead to language communication disorders, empathy disorders, difficulties in interpreting social cues, abnormal social reward processing and emotional regulation disorders, which are closely related to ASD social impairment. Noninvasive brain stimulation of the superficial cerebellum can improve the abnormal CC circuit in ASD patients, and the cerebellum can be considered as a target for the treatment of social disorders in ASD in the future.Based on the clinical and basic researches on social impairment in ASD in recent years, this article reviews the relevant manifestations of disorders which cerebellar and CC circuit involved, aiming to promote the development of related research in the future.
