Correlation between stereotyped repetitive behaviors and auditory event-related potentials in children with Asperger syndrome
10.3760/cma.j.cn371468-20241116-00545
- VernacularTitle:阿斯伯格综合征儿童刻板重复行为与听觉事件相关电位的关系
- Author:
Yiying HUANG
1
;
Wei ZHENG
1
Author Information
1. 厦门市精神卫生中心（厦门市仙岳医院）儿童心理科，厦门 361012
- Publication Type:Journal Article
- Keywords:
Asperger syndrome;
Stereotypical repetitive behaviors;
Auditory event-related potentials;
Child
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2025;34(4):309-315
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between stereotyped repetitive behaviors and auditory event-related potential(ERP) components P50, N1, P2, N2, and P3 in children with Asperger syndrome(AS).Methods:Forty children with AS and twenty age- and gender-matched healthy children were selected as the AS group and the control group, respectively. Auditory ERP components P50, N1, P2, N2, and P3 were measured in both groups. The AS group were evaluated by the childhood Asperger syndrome test (CAST), autism spectrum screening questionnaire, mandarin Chinese version(CH-ASSQ), and aberrant behavior checklist (ABC).The SPSS 24.0 software was used to perform independent sample t-test on the differences in ERP components between the two groups. Pearson correlation analysis, Spearman correlation analysis and multiple linear regression analysis were performed on the scores of stereotyped repetitive behaviors and the amplitude and latency of ERP components. Results:The P50 amplitude ratio (S2/S1) in the AS group was significantly higher than that in the control group((89.6±49.5)% vs (58.3±28.9)%, t=2.950, P=0.005). The latencies of N1 ((111.0±19.7) ms vs (90.9±22.0) ms, t=3.515, P<0.001), P2 ((167.5±21.5) ms vs (142.2±27.2) ms, t=3.841, P<0.001), N2 ((220.0±20.5) ms vs (192.1±26.9) ms, t=4.364, P<0.001), P3a ((297.5±21.9) ms vs (270.3±29.4) ms, t=3.931, P<0.001), and P3b ((376.9±19.4) ms vs (350.6±26.8) ms, t=3.865, P<0.001) in the AS group were all longer than those in the control group. After controlling for comorbidities such as ADHD, age, and Wechsler intelligence quotient for children, the total score of stereotyped behaviors of the ABC showed positive partial correlations with the S1 amplitude( r=0.478), S1 latency( r=0.667), and S2 latency( r=0.510) of P50, as well as the latencies of P3a( r=0.428) and P3b( r=0.470)(all P<0.05).The results of multiple linear regression analysis showed that age and N2 latency were the influencing factors of the total score of restricted and repetitive behaviors ( β=0.500, 0.520, both P<0.05), and S1-P50 amplitude and N2 latency were the influencing factors of the total score of stereotyped behaviors ( β=0.609, 0.518, both P<0.05). Conclusion:Restricted and repetitive behaviors are not in a simple linear relationship with ERP components. Stereotyped behaviors may be associated with decreased stimulus sensitivity and impaired higher-order cognitive functions. The N2 latency may be a potential biomarker for predicting stereotyped repetitive behaviors.
