Discussion on the Relationship Between Gastroesophageal Reflux Disease And lnsomnia Based on"Stomach Disharmony Leads to Testlessness":A Two-Sample Mendel Randomized Study
10.11842/wst.20240717003
- VernacularTitle:基于"胃不和则卧不安"探讨胃食管反流病和失眠的关联性:一项两样本孟德尔随机化研究
- Author:
Qianyan WU
1
;
Xiaogang XU
1
;
Qingyuan ZHANG
1
;
Jingwen ZHANG
1
;
Delin ZHANG
1
Author Information
1. 江西中医药大学中医学院 南昌 330004
- Publication Type:Journal Article
- Keywords:
Disharmony of stomach leads to restlessness;
Gastroesophageal reflux disease;
Insomnia;
Relevance;
Mendel randomization
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(3):867-877
- CountryChina
- Language:Chinese
-
Abstract:
Objective Based on the theory of"stomach disharmony leads to restlessness",the causal relationship between gastroesophageal reflux disease and insomnia was discussed by Mendel randomization method with two samples.Methods The data were collected from genome-wide association studies,the exposure factor was gastroesophageal reflux disease,and the outcome variable was insomnia.Mendel randomization analysis is realized by inverse variance weighted method,MR-Egger method,simple model method,weighted model method and weighted median method.Sensitivity analysis includes pleiotropic test,heterogeneity test and one-by-one elimination test,and is calculated by MR-Egger method,Cochran Q test and one-out-of-one method in turn.Results A total of 75 single nucleotide polymorphisms(SNPs)were screened.The inverse variance weighted method showed that gastroesophageal reflux disease increased the risk of insomnia(OR=1.255,95%CI:1.071-1.470,P<0.05).The weighted median method also confirmed that there was a positive causal relationship between gastroesophageal reflux disease and insomnia(OR=1.403,95%CI:1.117-1.762,P<0.05).Multiple sensitivity analysis indicated that there was no pleiotropy and heterogeneity in the results of Mendelian randomized analysis,which verified the stability of the research results.Conclusion There is a positive causal relationship between gastroesophageal reflux disease and insomnia,which enriches the theoretical connotation of"stomach disharmony leads to restlessness"from the genetic point of view and lays a foundation for further study.
