Based on the lmbalance of Estrogen Levels and Estrogen Receptor Expression Exploring How Chinese Medical Master Xiao Chengcong Uses the Harmonization Method to Treat(Peri)Menopausal lnsomnia
10.11842/wst.20240612002
- VernacularTitle:基于雌激素水平及雌激素受体表达失衡探讨国医大师肖承悰运用"和法"治疗(围)绝经期失眠
- Author:
Linna JIA
1
;
Ling TANG
;
Tianlin SUN
;
Shuang MIAO
Author Information
1. 北京市昌平区中医医院 北京 102200
- Publication Type:Journal Article
- Keywords:
Estrogen;
Estrogen receptor;
(Peri)Menopausal insomnia;
Xiao Chengcong;
The harmonizing method;
Gengxin decoction
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(3):887-893
- CountryChina
- Language:Chinese
-
Abstract:
(Peri)Menopausal insomnia is one of the most common symptoms experienced by women in(peri)menopausale,and can cause varying degrees of damage to both the physical and mental health of individuals.Modern medicine believes that the decline in estrogen levels and the imbalance in estrogen receptor expression are closely related to the occurrence of(peri)menopausale insomnia in women.Traditional Chinese Medicine believes that the imbalance of yin and yang in the body,caused by the disharmony between the heart and kidney,is an important factor in the onset of this disease.Professor Xiao Chengcong,a renowned master of traditional Chinese medicine,has summarized years of clinical experience and has developed a unique therapeutic approach for this disease using the harmonizing method.Her self-designed empirical formula,Gengxin Decoction,has been proven to have a good therapeutic effect in clinical trials.The team has further confirmed in animal studies that Gengxin Decoction can increase estrogen levels,promote estrogen receptor expression in the hypothalamus,influence the regulation of monoamine neurotransmitters,enhance the negative gene expression of the biological clock,reduce brain excitability,and restore the circadian rhythm of the biological clock.This article discusses the decline in estrogen levels and the imbalance in estrogen receptor expression which promote the occurrence and development of(peri)menopausal insomnia,the role of Gengxin Decoction and the harmonizing method in the etiology and pathogenesis of(peri)menopausal insomnia,and the alignment between the physiological effects of Gengxin Decoction and the balance of estrogen levels and estrogen receptor expression,aiming to reveal the scientific connotation of Professor Xiao Chengcong's use of the harmonizing method to treat(peri)menopausal insomnia,to provide a reference for clinical treatment,and to promote the dissemination and inheritance of the academic thoughts of traditional Chinese medicine master Professor.
