Research Progress on Apoptosis,Pyroptosis and Necroptosis in the Treatment of Colorectal Cancer
- VernacularTitle:细胞凋亡、焦亡与坏死性凋亡在结直肠癌治疗中的研究进展
- Author:
Shiping YU
1
;
Nan ZHANG
;
Weiyi SUN
;
Qiang ZHI
;
Junsheng SHA
;
Shu CHEN
;
Nan GAO
Author Information
- Publication Type:Journal Article
- Keywords: Colorectal cancer; Integrated traditional Chinese and western medicine; Cell apoptosis; Pyroptosis; Necroptosis; Interaction; Clinical treatment
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(3):633-642
- CountryChina
- Language:Chinese
- Abstract: Colorectal cancer(CRC)is a malignant tumor formed in the colon or rectum,usually caused by uncontrolled growth and division of normal cells in the body.Cell apoptosis,pyroptosis,and necroptosis are key pathways of cell death in colorectal cancer.The comprehensive treatment strategy includes the synergistic effect of cell death inducers with chemotherapy,immunotherapy,and targeted therapy.Traditional Chinese medicine plays an important role as an adjuvant therapy in regulating cell death.The combination of traditional Chinese and western medicine has shown significant effects in precancerous lesions,improving efficacy,reducing adverse reactions,and reducing drug resistance.Although the research on the mechanism of cell death is not yet sufficient,emphasizing the unique characteristics of traditional Chinese medicine,clarifying the anti-tumor mechanism of traditional Chinese medicine,and achieving modern scientific internationalization of integrated traditional Chinese and western medicine treatment for colorectal cancer have become future research directions.This article will comprehensively review the molecular mechanisms of cell apoptosis,pyroptosis,and necroptosis from the perspective of combining traditional Chinese and Western medicine,as well as their regulatory role in the treatment of colorectal cancer.
