Relationship between different types of diabetes and the risk of glaucoma:a bidirectional Mendelian randomization study
10.13389/j.cnki.rao.2025.0067
- VernacularTitle:不同类型糖尿病与青光眼发病风险的相关性:基于双向孟德尔随机化研究
- Author:
Lu YU
1
;
Min DONG
;
Kuiliang YANG
;
Ning YANG
;
Yiqiao XING
Author Information
1. 430000 湖北省武汉市,武汉大学人民医院眼科中心;430000 湖北省武汉市,武汉大学附属爱尔眼科医院
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
gestational diabetes mellitus;
type 1 diabetes mellitus;
glaucoma;
Mendelian randomization
- From:
Recent Advances in Ophthalmology
2025;45(5):382-386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between different diabetes mellitus(DM)subtypes and the inci-dence of glaucoma through bidirectional Mendelian randomization(MR)analysis.Methods Based on a bidirectional MR analysis framework,the highly correlated single nucleotide polymorphism(SNP)was selected from the genome-wide asso-ciation study(GWAS)data as the instrumental variable(Ⅳ)for three DM subtypes[including type 1 diabetes mellitus(T1DM),type 2 diabetes mellitus(T2DM),and gestational diabetes mellitus(GDM)]and glaucoma to analyze the bidi-rectional causal relationship between different DM subtypes and glaucoma.Besides,the MR-Egger method,weighted medi-an method,inverse-variance weighted method,simple random model,and weighted mode method were adopted to conduct a comprehensive analysis,and the obtained results were subjected to sensitivity analyses.Results The bidirectional MR analysis results revealed no causal association between T1DM and glaucoma.The forward MR analysis results indicated that T2DM may promote the development of glaucoma(IVW:OR=1.09,95％CI:1.05～1.14),while the development of glau-coma did not increase the risk of T2DM.Meanwhile,the multivariable MR analysis results showed that T2DM might be a potential risk factor for the development of glaucoma.The forward MR analysis results demonstrated that GDM did not in-crease the incidence of glaucoma;whereas the reverse MR analysis results suggested that glaucoma might increase the sus-ceptibility to GDM(IVW:OR=1.11,95％CI:1.02～1.21).The sensitivity analysis results confirmed the stability and relia-bility of these findings.Conclusion T2DM may contribute to the development of glaucoma,and patients with glaucoma may exhibit heightened susceptibility to GDM during pregnancy.
