Effects of different plasma/red blood cell suspension ratios on prothrombin time, activated partial thromboplastin time, and fibrinogen level in patients with postpartum hemorrhage
10.3760/cma.j.cn341190-20241205-01629
- VernacularTitle:不同血浆/悬浮红细胞配比方案对产后大出血患者PT、APTT、Fb水平的影响
- Author:
Jie LI
1
;
Hongxin LI
;
Youzhong XING
Author Information
1. 济南市中心医院输血科，济南 250013
- Publication Type:Journal Article
- Keywords:
Postpartum hemorrhage;
Plasma;
Erythrocytes;
Prothrombin time;
Fibrinogen;
Transfusion reaction
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(10):1460-1465
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of different plasma/red blood cell suspension ratios on prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen (Fb) level in patients with postpartum hemorrhage, providing evidence for rational blood transfusion in clinical practice.Methods:This study used a retrospective design. The clinical data of 128 patients with postpartum hemorrhage admitted to Jinan Central Hospital from January 2020 to December 2023 were analyzed. The patients were divided into a control group and an observation group, with 64 patients in each group, based on different transfusion protocols. The control group received transfusion therapy using a conventional plasma/red blood cell suspension ratio, while the observation group was treated with an optimized ratio scheme. The PT, APTT, and Fb levels were compared between the two groups before and after blood transfusion. The amount of bleeding, the volume of blood transfused, and the incidence of complications were recorded and compared between the two groups.Results:Before transfusion, there were no statistically significant differences in PT, APTT, or Fb levels between the two groups (all P>0.05). After transfusion, PT and APTT in the observation group were (11.53 ± 1.08) seconds and (32.00 ± 3.00) seconds, respectively, which were significantly shorter than those in the control group [(13.02 ± 1.57) seconds, (35.00 ± 4.00) seconds, t = 8.01, 6.01, both P<0.001]. Fb levels in the observation group were significantly higher than those in the control group [(2.24 ± 0.37) g/L vs. (1.83 ± 0.47) g/L, t = 5.48, P<0.001]. The amount of bleeding and the volume of red blood cell suspension transfused in the observation group were (800 ± 150) mL and (600 ± 80) mL, respectively, which were significantly lower than those in the control group [ (1 200 ± 200) mL, (800 ± 100) mL, t = 12.01, 10.01, both P<0.001]. There was no statistically significant difference in the volume of blood transfused between the two groups ( t = 0.00, P = 1.000). The incidence of complications in the observation group was significantly lower than that in the control group [10.94% (7/64) vs. 20.31% (13/64), χ2 = 4.60, P = 0.032]. Conclusions:The optimized plasma/red blood cell suspension ratio can effectively improve the coagulation function of patients with postpartum hemorrhage, reduce bleeding and transfusion-related complications.
