Research on Lung Cancer Traditional Chinese Medicine Prescription Recommendation Based on Large Language Models
10.14148/j.issn.1672-0482.2025.0980
- VernacularTitle:基于大语言模型的肺癌中药处方推荐研究
- Author:
Zongzhen ZHOU
1
;
Xinyu WANG
;
Tao YANG
;
Kongfa HU
Author Information
1. 南京中医药大学人工智能与信息技术学院,江苏 南京 210023;江苏省智慧中医药健康服务工程研究中心,江苏 南京 210023
- Publication Type:Journal Article
- Keywords:
large language model;
prescription recommendation;
traditional Chinese medicine;
text generation;
lung cancer;
GLM structure;
CHATGLM3 model
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(7):980-986
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To address the issue of recommending traditional Chinese medicine(TCM)prescriptions,and to utilize the clinical records of lung cancer from TCM experts to automatically generate prescriptions,providing reference for the study of medi-cation rules and TCM clinical decision-making assistance.METHODS This algorithm transformed clinical manifestations,standard-ized tongue diagnosis,and pulse diagnosis into TCM prescriptions through a large model,thereby converting the task of TCM prescrip-tion recommendation into a text generation task.The CHATGLM3 model,based on the GLM structure,was used to enhance the under-standing of lung cancer cases and learn the intrinsic experiential knowledge of TCM experts in treating lung cancer,thereby improving the prescription generation effectiveness of the model.This was compared with traditional generative models.RESULTS The study demonstrated that integrating TCM knowledge from lung cancer cases into large language models effectively improved the model's pre-scription generation capabilities.Particularly in generating commonly used core medications by TCM experts,the model showed a high tendency and provided rich and valuable reference information.The lung cancer TCM prescription recommendation model achieved 64.62%in BLEU,55.78%in ROUGE,and 47.39%in METEOR scores.It also achieved accuracies of 67.79%,63.66%,56.76%,and 51.93%in the top 5,10,15,and 20 TCM prescriptions,respectively,outperforming the baseline model.CONCLUSION The lung cancer TCM prescription recommendation model presented in this paper achieves better prescription generation results com-pared to traditional generative models.It demonstrates the model's ability to learn knowledge about lung cancer diagnosis and treatment from cases,thereby generating TCM prescriptions that align with TCM treatment principles.This also provides a potential direction for future assistance in clinical decision-making.
