Mendelian randomization reveals the effect of plasma lipidomics on pan-creatitis
10.3969/j.issn.1009-9905.2025.06.003
- VernacularTitle:孟德尔随机化揭示血浆脂质组学对胰腺炎的影响
- Author:
Qi-rong JIANG
1
;
Zhe-yu NIU
1
;
Fa-ji YANG
1
;
Yi-jie HAO
1
;
Shi-zhe ZHANG
1
;
Jun LU
1
Author Information
1. 山东第一医科大学附属省立医院 胆胰外科(山东 济南 250000)
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Plasma lipidomics;
Intra-pancreatic fat deposition;
Gallstone disease;
Mendelian random-izatio
- From:
Chinese Journal of Current Advances in General Surgery
2025;28(6):436-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the causal effects of plasma lipidomics on pancreatitis using Mendelian ran-domization(MR)and evaluate the roles of intra-pancreatic fat deposition(IPFD)and gallstone disease in this relation-ship.Methods:A bidirectional MR analysis was conducted,with 179 plasma lipids as exposures and acute pancreati-tis(AP)and chronic pancreatitis(CP)as outcomes.Data were sourced from genome-wide association studies(GWAS),the UK Biobank,and the FinnGen project.Two-step Mendelian randomization(TSMR)and multivariable Mendelian ran-domization(MVMR)analyses were applied to assess the mediating roles of IPFD and gallstone disease in the associa-tion between plasma lipids and pancreatitis.Results:MR analysis identified two sterols negatively associated with AP(P＜0.05)and seven sterols negatively associated with CP(P＜0.05).One phospholipid showed a positive association with CP(P＜0.05).IPFD was positively associated with both AP and CP.Gallstone disease was confirmed as a risk fac-tor for AP.However,TSMR analysis indicated that neither IPFD nor gallstone disease mediated the relationship be-tween plasma lipids and pancreatitis.Conclusion:The causal relationship exists among plasma lipomics and AP/CP,also between IPFD,cholelithiasis and pancreatitis.These findings highlight novel risk factors and potential biomarkers to support early diagnosis and intervention for pancreatitis.
